Histone H2A.X (Ab-139) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityHistone H2A.X (Ab-139)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatepitope affinity purified
Size0.05 mL, 0.1 mL
Concentration1.0 mg/ml
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
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DescriptionThe antibody detects endogenous level of total Histone H2A.X protein. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when
ImmunogenImmunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.137~141 (Q-A-S-Q-E) derived from Human Histone H2A.X.
Other Names[H2A.X; H2AFX; H2a/x; HIST5-2AX]
Gene, Accession #Gene ID: 3014, NCBI: NP_002096.1, UniProt: P16104
Catalog #MBS9402990
Price$200, $255
Order / More InfoHistone H2A.X (Ab-139) Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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