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Antigenic Specificity | Histone H2A.X (Ab-139) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total Histone H2A.X protein. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.137~141 (Q-A-S-Q-E) derived from Human Histone H2A.X. |
Other Names | [H2A.X; H2AFX; H2a/x; HIST5-2AX] |
Gene, Accession # | Gene ID: 3014, NCBI: NP_002096.1, UniProt: P16104 |
Catalog # | MBS9402990 |
Price | $200, $255 |
Order / More Info | Histone H2A.X (Ab-139) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |