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Antigenic Specificity | PARP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total PARP1 antibody. PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress (1). This protein can be cleaved by many ICE-like caspases in vitro (2,3) and is one of the main cleavage targets of caspase-3 in vivo (4,5). In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) (2,4). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis (6). |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human PARP1. |
Other Names | [ADPRT; ADPRT1; PARP; PARP-1; PPOL; pADPRT-1] |
Gene, Accession # | [PARP1], Gene ID: 142, NCBI: NP_001609.2, UniProt: P09874 |
Catalog # | MBS9400968 |
Price | $255 |
Order / More Info | PARP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |