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Antigenic Specificity | BMI1 |
Clone | [282CT3.7.6] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1,k |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This BMI1 monoclonal antibody is generated from mouse immunized with BMI1 recombinant protein. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
Immunogen | n/a |
Other Names | [Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; PCGF4; RNF51] |
Gene, Accession # | [BMI1], Gene ID: 100532731, NCBI: NP_001190991.1, UniProt: P35226 |
Catalog # | MBS9200047 |
Price | $370 |
Order / More Info | BMI1 Antibody from MYBIOSOURCE INC. |
Product Specific References | Ismail, I.H., et al. J. Cell Biol. 191(1):45-60(2010) Yang, M.H., et al. Nat. Cell Biol. 12(10):982-992(2010) Kikuchi, J., et al. Cancer 116(12):3015-3024(2010) Honig, A., et al. Anticancer Res. 30(5):1559-1564(2010) Venkataraman, S., et al. PLoS ONE 5 (6), E10748 (2010) : |