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Antigenic Specificity | KDM6A (Center) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This KDM6A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 797-832 amino acids from the Central region of human KDM6A. Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. |
Immunogen | n/a |
Other Names | [Lysine-specific demethylase 6A; 11411-; Histone demethylase UTX; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein; KDM6A; UTX] |
Gene, Accession # | [KDM6A], Gene ID: 7403, NCBI: NP_066963.2, UniProt: O15550 |
Catalog # | MBS9201376 |
Price | $165, $370 |
Order / More Info | KDM6A (Center) Antibody from MYBIOSOURCE INC. |
Product Specific References | Lahn B.T.,et al.Science 278:675-680(1997). Ross M.T.,et al.Nature 434:325-337(2005). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Cho Y.-W.,et al.J. Biol. Chem. 282:20395-20406(2007). Lan F.,et al.Nature 449:689-694(2007). |