Phospho-EIF4EBP1-S65 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-EIF4EBP1-S65 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation (1). Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity (2, 3). Multiple 4E-BP1 residues are phosphorylated in vivo (4). While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E-BP1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70 (5). |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S65 of human EIF4EBP1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [4E-BP1; 4EBP1; BP-1; MGC4316; PHAS-I] |
| Gene, Accession # | [EIF4EBP1-S65], Gene ID: 1978, NCBI: NP_004086.1, UniProt: Q13541 |
| Catalog # | MBS8527420 |
| Price | $310 |
| Order / More Info | Phospho-EIF4EBP1-S65 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Pause, A. et al. (1994) Nature 371, 762-767. 2. Brunn, G.J. et al. (1997) Science 277, 99-101. 3. Gingras, A.C. et al. (1998) Genes Dev. 12, 502-513. 4. Fadden, P. et al. (1997) J. Biol. Chem. 272, 10240-10247. 5. Gingras, A.C. et al. (1999) Genes Dev. 13, 1422-1437. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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