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Antigenic Specificity | DOK3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: DOK3 antibody detects endogenous levels of total DOK3. Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).Subunit Structure: On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL1 through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP (By similarity).Post-translational Modificat |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Cytoplasm. Cell Membrane. Tissue Specificity: Expressed in spleen. |
Other Names | [Docking protein 3; DOK 3; DOK Like Protein; Dok3; DOK3_HUMAN; DOKL Pending; Downstream of tyrosine kinase 3; p62 DOK Like Protein] |
Gene, Accession # | [DOK3], Gene ID: 79930, NCBI: NP_001138347.1, UniProt: Q7L591 |
Catalog # | MBS9604792 |
Price | $240, $280 |
Order / More Info | DOK3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |