C-MYC Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | C-MYC |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: MYC antibody detects endogenous levels of total MYC. Description: Myc a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.Function: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000).Subunit Structure: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (PubMed:9680483). Interacts with TAF1C |
| Immunogen | Immunogen: A synthesized peptide derived from human MYC Subcellular Location: Nucleus > Nucleoplasm. Nucleus > Nucleolus. |
| Other Names | [AU016757; Avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; Class E basic helix-loop-helix protein 39; MRTL; Myc; Myc protein; Myc proto oncogene protein; Myc proto-oncogene protein; myc-related translation/localization regulatory factor; MYC_HUMAN; Myc2; MYCC; Myelocytomatosis oncogene; Niard; Nird; Oncogene Myc; OTTHUMP00000158589; Proto-oncogene c-Myc; Protooncogene homologous to myelocytomatosis virus; RNCMYC; Transcription factor p64; Transcriptional regulator Myc-A; V-Myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog (avian)] |
| Gene, Accession # | [MYC], Gene ID: 4609, NCBI: NP_002458.2, UniProt: P01106 |
| Catalog # | MBS9600292 |
| Price | $240, $280 |
| Order / More Info | C-MYC Antibody from MYBIOSOURCE INC. |
| Product Specific References | Zhang Q, Wang C, Miao S, Li C, Chen Z, Li F; Journal: Oncotarget. Enhancing E-cadherin expression via promoter-targeted miR-373 suppresses bladder cancer cells growth and metastasis. Tang H, Peng F, Huang X, Xie X, Chen B, Shen J, Gao F, You J, Xie X, Chen J; Journal: Curr Cancer Drug Targets. Neoisoliquiritigenin Inhibits Tumor Progression by Targeting GRP78-beta-catenin Signaling in Breast Cancer. Li C, Liu J, Zhang Q, Cui K, Ge Q, Wang C, Chen Z; Journal: Int J Oncol. Upregulation of E-cadherin expression mediated by a novel dsRNA suppresses the growth and metastasis of bladder cancer cells by inhibiting beta-catenin/TCF target genes. Luo S, Pan Z, Liu S, Yuan S, Yan N; Journal: Oncol Lett. Sphingomyelin synthase 2 overexpression promotes cisplatin-induced apoptosis of HepG2 cells. Tong Lu, Huayou Luo, Jia Liu, Cheng Chen, Feng Wang, Zongwen Shen, Tonglei Liu, Yujian Zeng, Ting-Hua Wang, Kun-Hua Wang; Journal: Int J Clin Exp Pathol. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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