BCR Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | BCR |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.1 mg |
| Concentration | 1ug/ul |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Bcr (phospho-Tyr177) antibody detects endogenous levels of Bcr only when phosphorylated at tyrosine 177. A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encod |
| Immunogen | Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Bcr around the phosphorylation site of tyrosine 177 (P-F-Y-VP-N). |
| Other Names | n/a |
| Gene, Accession # | [BCR] |
| Catalog # | MBS416959 |
| Price | $325 |
| Order / More Info | BCR Antibody from MYBIOSOURCE INC. |
| Product Specific References | Sattler M, et al. Mol Cell Biol. 1999 Nov; 19(11): 7473-7480.Li S et al. EMBO J. 2001 Dec 3; 20(23): 6793-6804.Million RP, et,al. Mol Cell Biol. 2004 Jun; 24(11): 4685-4695.Malcolm A. Meyn, et al. Biol. Chem., Oct 2006; 281: 30907 - 30916. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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