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Antigenic Specificity | Histone H2AX |
Clone | [RM214] |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | Protein A purified |
Size | 0.025 mg |
Concentration | 1 mg/ml |
Applications | Western Blot (WB); Immunocytochemistry (ICC); ELISA (EIA); Multiplex |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit monoclonal antibody to detect Histone H2AX. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin; limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation; DNA repair; DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones; also called histone code; and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-termi |
Immunogen | Immunogen: A peptide corresponding to the C-terminus of human Histone H2AX |
Other Names | [H3F3A; H3.3A; H3F3; H3F3B; H3.3B], [H2AFX] |
Gene, Accession # | [H2AX], Gene ID: 3014, NCBI: NP_002096.1, UniProt: P16104 |
Catalog # | MBS846021 |
Price | $245 |
Order / More Info | Histone H2AX Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |