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Antigenic Specificity | Prion Protein, Chicken |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | unconjugated |
Size | 0.2 mL |
Concentration | n/a |
Applications | Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Prion protein is the protein responsible for human Creutzfeldt-Jakob Disease (CJD), and somatic mutations of the prion gene are responsible for Gerstmann-Straussler-Scheinker disease and Fatal Familial Insomnia. The bovine homolog of the prion protein is responsible for bovine Spongioform Encephalopathy (BSE), also known as Mad Cow Disease. In all cases, the prion protein has two folding states, with one state being the normal non-pathological form, and the other state inducing a spongioform encephalopathy. Normal prion proteins produced naturally in the brain interact with the amyloid-b peptides that are hallmarks of Alzheimer's disease. Blocking this interaction in preparations made from mouse brains halted some neurological defects c |
Immunogen | Immunogen: Recombinant fragment of the Human Prion |
Other Names | [Prion protein; Major prion protein; alternative prion protein; major prion protein; prion protein; ASCR; PrP27-30; PrP33-35C; CD_antigen: CD230], [PRNP; PRNP; CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C; ALTPRP; PRIP; PRP; PrP] |
Gene, Accession # | [CD230], Gene ID: 5621, NCBI: AAH22532.1 |
Catalog # | MBS555366 |
Price | $430 |
Order / More Info | Prion Protein, Chicken Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |