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Antigenic Specificity | MSH6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, monkey |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between nonidentical DNA sequences, and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-alpha dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-alpha is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins, and the Rad50-Mre11-NBS1 complex (2). Mutations in MSH6 and other MMR proteins have been found in a large proportion of hereditary nonpolyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world (3). Mutatio |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [MSH6; GTBP; HNPCC5; HSAP], [MSH6; MSH6; GTBP; HSAP; p160; GTMBP; HNPCC5; GTBP; hMSH6; GTBP; GTMBP; p160] |
Gene, Accession # | [MSH6], Gene ID: 2956, NCBI: P52701.2, UniProt: P52701 |
Catalog # | MBS126788 |
Price | $200, $275, $430 |
Order / More Info | MSH6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |