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Antigenic Specificity | MADD |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunoblot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Anti-MADD (CT) [Rabbit antibody to peptide corresponding to aa 1570-1588 of human MADD. Recognizes human and mouse MADD.]. This antibody recognizes human and mouse MADD (200-220 kD). MAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1). Overexpression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2. MADD shares 98% homology with DENN (differentially expressed in neoplasic vs. normal cells) which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3). MADD has greather than 94% homology with a GDO/GTP exchange protein , Rab3-GEP, and it is 87% homologous with KIAA0358, a brain pr |
Immunogen | Antigen: Peptide corresponding to aa 1570-1588 of human MADD. This peptide sequence is identical to that of DENN and differs by one amino acid with rat GDP/GTP exchange protein RAB3-GEP. |
Other Names | [MADD (CT); MADD], [MADD; DENN; DENN; IG20; RAB3GEP; FLJ35600; FLJ36300; KIAA0358] |
Gene, Accession # | Gene ID: 8567, NCBI: NP_001129416.1, UniProt: Q7KYV8 |
Catalog # | MBS194115 |
Price | $415 |
Order / More Info | MADD Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |