ARHGEF7 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityARHGEF7
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formataffinity purified
Size0.1 mg
Concentration1mg/ml
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionSpecificity: Western blot analysis of extracts of various cell lines, using ARHGEF7 antibody. Cool/Pix proteins comprise a family of guanine nucleotide exchange factors (GEFs) localized to focal adhesions. The family consists of two isoforms, cool2/+/-pix and cool1/2Pix, the latter having two splice variants that vary in their carboxy termini (1). Cool1/2Pix, like other GEFs, has a DH (Dbl homology) domain, which allows binding of small GTPases and GDP/GTP exchange, and a PH (Pleckstrin homology) domain, which is important in regulating subcellular localization. Cool1/2Pix also has an SH3 domain, which binds to the PAK kinase, a downstream effector of cdc42 and Rac (3, 4). Phosphorylation of cool1/2Pix by PAK2 downstream of MAPK signaling a
ImmunogenImmunogen: Recombinant protein of human ARHGEF7
Other Names[ARHGEF7, partial; Rho guanine nucleotide exchange factor 7; rho guanine nucleotide exchange factor 7; Rho guanine nucleotide exchange factor 7; Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85], [ARHGEF7; ARHGEF7; P50; P85; PAK3; PIXB; COOL1; P50BP; COOL-1; P85SPR; BETA-PIX; P85COOL1; Nbla10314; COOL1; KIAA0142; P85SPR; PAK3BP; PIXB]
Gene, Accession #[ARHGEF7], Gene ID: 8874, NCBI: CAH59949.1
Catalog #MBS419541
Price$385
Order / More InfoARHGEF7 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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