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Antigenic Specificity | Mouse CD105 |
Clone | [MJ7/18] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2a kappa |
Format | unconjugated |
Size | 0.5 mg |
Concentration | n/a |
Applications | Flow Cytometry; Immunocytochemistry; Immunohistochemistry (Frozen Sections); Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Mouse endoglin, Mr 90kDa. CD105/endoglin is a disulfide-linked type II transmembrane homodimer that is predominantly expressed on vascular endothelial cells. It is also found on pre-erythroblasts, macrophages and lymphoid and myeloid leukemic cells.2 Both mouse and human CD105 exhibit >70% sequence homology in their cytoplasmic domains with type III transforming growth factor beta (TGF beta) receptor.3 CD105 has been shown to be one of several receptors for the various isoforms of TGF beta, which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells and control of the immune response.4. |
Immunogen | Immunogen: Inflamed mouse skin |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS673616 |
Price | $285 |
Order / More Info | Mouse CD105 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Ge, A.Z.,, and E.C. Butcher. 1994. Gene 138:201.2. Letarte, M., A. Greaves, and S. Vera. 1995. CD105 (endoglin) cluster report. In: Leucocyte Typing V, White Cell Differentiation Antigens. Eds. Schlossman, S., L. Boumsell, W. Gilks, J.M. Harlan, T Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R. Silverstein, T. Springer, T.F. Tedder, and R.F. Todd. Oxford University Press, p. 1756.3. Berg, e., et al. 1989. Homing receptors and vascular addressins: cell adhesion molecules that direct lymphocyte traffic. Immunol. Rev. 108:5.4. Lastres, P., et al. 1996. J. Cell. Biol. 133:1109. |