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Antigenic Specificity | DNAJB14 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed: |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human DNAJB14 (NP 001026893.1). |
Other Names | [EGNR9427; PRO34683] |
Gene, Accession # | [DNAJB14], NCBI: NP_001026893.1, UniProt: Q8TBM8 |
Catalog # | MBS8545446 |
Price | $280 |
Order / More Info | DNAJB14 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |