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Antigenic Specificity | PSMD10 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-226 of human PSMD10 (NP 002805.1). |
Other Names | [p28; p28(GANK; dJ889N15.2] |
Gene, Accession # | [PSMD10], Gene ID: 5716, NCBI: O75832.1, UniProt: O75832 |
Catalog # | MBS8544692 |
Price | $280 |
Order / More Info | PSMD10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |