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Antigenic Specificity | SKP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human SKP1 (NP 733779.1). |
Other Names | [OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L] |
Gene, Accession # | [SKP1], Gene ID: 6500, NCBI: NP_008861.2, UniProt: P63208 |
Catalog # | MBS8544996 |
Price | $280 |
Order / More Info | SKP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |