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Antigenic Specificity | ACTN1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | alpha-Actinin belongs to the spectrin family of cytoskeletal proteins. It was first recognized as an actin cross-linking protein, forming an antiparallel homodimer with an actin binding head at the amino terminus of each monomer. More recently, alpha-actinin has been shown to interact with a large number of proteins involved in signaling to the cytoskeleton including those involved in cellular adhesion, migration, and immune cell targeting (1). The interaction of alpha-actinin with intercellular adhesion molecule-5 (ICAM-5) helps to promote neurite outgrowth (2). In osteoblasts, interaction of alpha-actinin with integrins stabilizes focal adhesions and may protect cells from apoptosis (3). Isoforms 1 and 4 of alpha-actinin, which are non-mu |
Immunogen | Immunogen: Recombinant protein of human ACTN1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [ACTN1; FLJ40884; FLJ54432] |
Gene, Accession # | [ACTN1], Gene ID: 87, NCBI: NP_001093.1, UniProt: P12814 |
Catalog # | MBS8502631 |
Price | $310 |
Order / More Info | ACTN1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Otey, C.A. and Carpen, O. (2004) Cell Motil. Cytoskeleton 58, 104-111. 2. Nyman-Huttunen, H. et al. (2006) J. Cell Sci. 119, 3057-3066. 3. Triplett, J.W. and Pavalko, F.M. (2006) Am. J. Physiol. Cell Physiol. 291, C909-921. |