SIAH1, E3 Ubiquitin Ligase Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | SIAH1, E3 Ubiquitin Ligase |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | ammonium sulfate precipitate |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Seven in absentia homolog 1 (SIAH-1) is a member of the RING-finger-containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson's disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress. |
| Immunogen | Immunogen: Synthetic peptide derived from the human SIAH-1 protein. |
| Other Names | [SIAH1 (seven in absentia homolog 1); E3 Ubiquitin Ligase], [SIAH1; SIAH1; SIAH1A; HUMSIAH; Siah-1] |
| Gene, Accession # | [SIAH1], Gene ID: 6477, NCBI: NP_001006611.1, UniProt: Q8IUQ4 |
| Catalog # | MBS395429 |
| Price | $340 |
| Order / More Info | SIAH1, E3 Ubiquitin Ligase Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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