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Antigenic Specificity | AURKC |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. |
Immunogen | Immunogen: A synthetic peptide of human AURKC |
Other Names | [AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C] |
Gene, Accession # | [AURKC], Gene ID: 6795, NCBI: NP_001015878.1, UniProt: Q9UQB9 |
Catalog # | MBS8547140 |
Price | $280 |
Order / More Info | AURKC Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |