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Antigenic Specificity | CD153 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Rabbit IgG polyclonal antibody for Tumor necrosis factor ligand superfamily member 8(TNFSF8) detection. Tested with IHC-P in Human. Background: CD153 is a ligand for CD30. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biolo |
Immunogen | Immunogen: E Coli-derived human CD153 recombinant protein (Position: Q63-D234). Human CD153 shares 75% amino acid (aa) sequence identity with mouse CD153. Ig Type: Rabbit IgG |
Other Names | [Tumor necrosis factor ligand superfamily member 8; CD153; CD153 antigen; CD30 antigen ligand; CD30 L; CD30 ligand; CD30-L; CD30L; CD30LG; MGC138144; TNFL8_HUMAN; Tnfsf8; Tumor necrosis factor (ligand) superfamily member 8; Tumor necrosis factor ligand superfamily member 8; tumor necrosis factor superfamily member 8], [TNFSF8; TNFSF8; CD153; CD30L; CD30LG; TNLG3A; CD30L; CD30LG; CD30-L] |
Gene, Accession # | [CD153], Gene ID: 944, NCBI: NP_001235.1, UniProt: P32971 |
Catalog # | MBS177945 |
Price | $315 |
Order / More Info | CD153 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Cerutti, A., Schaffer, A., Goodwin, R. G., Shah, S., Zan, H., Ely, S., Casali, P. Engagement of CD153 (CD30 ligand) by CD30-positive T cells inhibits class switch DNA recombination and antibody production in human IgD-positive IgM-positive B cells. J. Immun. 165: 786-794, 2000. 2. Croager, E. J., Abraham, L. J. Characterisation of the human CD30 ligand gene structure. Biochim. Biophys. Acta 1353: 231-235, 1997. 3. Fischer, M., Harvima, I. T., Carvalho, R. F. S., Moller, C., Naukkarinen, A., Enblad, G., Nilsson, G. Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. J. Clin. Invest. 116: 2748-2756, 2006. |