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Antigenic Specificity | MDA-7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: MDA-7 Polyclonal Antibody detects endogenous levels of MDA-7 protein. IL24 encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. Interleukin-24 encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been re |
Immunogen | Immunogen: Synthesized peptide derived from the internal region of human MDA-7 |
Other Names | [Rabbit MDA-7; IL24; MDA7; ST16; Interleukin-24; IL-24; Melanoma differentiation-associated gene 7 protein; MDA-7; Suppression of tumorigenicity 16 protein] |
Gene, Accession # | [MDA-7], Gene ID: 11009, NCBI: NP_001172085.1, UniProt: Q13007 |
Catalog # | MBS9703795 |
Price | $130, $220, $325 |
Order / More Info | MDA-7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |