APAF-1 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | APAF-1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | serum |
| Size | 0.05 mL |
| Concentration | n/a |
| Applications | Immunoprecipitation (IP), Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Apaf 1 (apoptosis protease-activating factor-1) is a key regulator of the mitochondrial apoptotic pathway, being the central element of the multimeric apoptosome. The apoptosome consists of cytochrome c, procaspase-9 and seven Apaf 1 monomers, and is considered to be core apoptotic machinery that executes mitochondria-dependent apoptosis. Cytochrome c, normally compartmentalized in the mitochorndria, is released into the cytoplasm following apoptotic stimuli. Apaf 1 binds cytochrome c in the cytoplasm and in the presence of dATP/ATP forms the apoptosome. The apoptosome binds procaspase-9 and promotes its autocatalytic activation. Active caspase-9, in turn, activates downstream caspases including 3, 6, and 7 contributing to the proteolytic c |
| Immunogen | Immunogen Information: A synthetic peptide of APAF-1 protein (amino acids 264-282 GPKYVVPVESSLGKEKGLE) was used as the immunogen for this antibody |
| Other Names | [APAF1; KIAA0413; Apoptotic protease-activating factor 1; to APAF-1; APAF-1; APAF-1], [APAF1; APAF1; CED4; APAF-1; KIAA0413; APAF-1] |
| Gene, Accession # | [APAF1], Gene ID: 317, NCBI: O14727.2, UniProt: O14727 |
| Catalog # | MBS668503 |
| Price | $270 |
| Order / More Info | APAF-1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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