Human Receptor tyrosine-protein kinase ErbB-3 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human Receptor tyrosine-protein kinase ErbB-3 |
| Clone | [DY-7G2] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), Immunohistochemistry(IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: anti-human Receptor tyrosine-protein kinase ErbB-3 (Her3). Background: ErbB-3 belongs to the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB receptors (EGFR (ErbB1), ErbB2, ErbB3, and ErbB4) are important regulators of normal growth and differentiation, and they are involved in the pathogenesis of cancer. The 148- kDa trans-membrane polypeptide ErbB-3 has a neuregulin binding domain but not an active kinase domain. Heterodimerisation with EGF receptor family members which possess kinase activity leads to the activation of pathways which indicate cell proliferation or differentiation (1). Over-expression of ErbB-3 has been reported in numerous cancers, including prostate, bladder and breast tumo |
| Immunogen | Immunogen: Immunogen: cDNA |
| Other Names | [Her3], [ERBB3; ERBB3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; HER3] |
| Gene, Accession # | Gene ID: 2065, NCBI: NP_001005915.1, UniProt: P21860 |
| Catalog # | MBS468038 |
| Price | $505 |
| Order / More Info | Human Receptor tyrosine-protein kinase ErbB-3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Kraus MH, Issing W, Miki T, Popescu NC, Aaronson SA (1989). Isolation and characterizationof ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence foroverexpression in a subset of human mammary tumors. Proc Natl Acad Sci USA, 86(23):9193-7Gullick WJ (1996). The c-erbB3/HER3 receptor in human cancer. Cancer Surv 27:339-49. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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