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Antigenic Specificity | KIDINS220 (C-term), 1518-1547 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This KIDINS220 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1518-1547 amino acids from the C-terminal region of human KIDINS220. KIDINS220 promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin-and ephrin-mediated neuronal outgrowth and in axon guidance during neural developm |
Immunogen | n/a |
Other Names | [Kinase D-interacting substrate of 220 kDa; Ankyrin repeat-rich membrane-spanning protein; KIDINS220; ARMS; KIAA1250] |
Gene, Accession # | [KIDINS220], Gene ID: 57498, NCBI: NP_065789.1, UniProt: Q9ULH0 |
Catalog # | MBS9213056 |
Price | $165, $370 |
Order / More Info | KIDINS220 (C-term), 1518-1547 Antibody from MYBIOSOURCE INC. |
Product Specific References | Wu, Z., et al. J. Biol. Chem. 283(42):28198-28215(2008) Sniderhan, L.F., et al. Mol. Cell. Neurosci. 38(3):404-416(2008) Li, J., et al. J. Biol. Chem. 283(5):2614-2621(2008) Liao, Y.H., et al. Cancer Res. 67(24):11547-11556(2007) Bracale, A., et al. Mol. Biol. Cell 18(1):142-152(2007) |