Edit |   |
---|---|
Antigenic Specificity | DBC-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: DBC-1 Polyclonal Antibody detects endogenous levels of DBC-1 protein. Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear horm |
Immunogen | Immunogen: Synthesized peptide derived from the internal region of human DBC-1 at AA range: 400-480 |
Other Names | [Rabbit DBC-1; KIAA1967; DBC1; DBIRD complex subunit KIAA1967; Deleted in breast cancer gene 1 protein; DBC-1; DBC.1; p30 DBC] |
Gene, Accession # | [DBC-1], Gene ID: 57805, NCBI: NP_066997.3, UniProt: Q8N163 |
Catalog # | MBS9706564 |
Price | $130, $220, $325 |
Order / More Info | DBC-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |