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Antigenic Specificity | SMAD6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 257-496 of human SMAD6 (NP 005576.3). |
Other Names | [AOVD2; MADH6; MADH7; HsT17432] |
Gene, Accession # | [SMAD6], Gene ID: 4091, NCBI: O43541.2, UniProt: O43541 |
Catalog # | MBS8549588 |
Price | $280 |
Order / More Info | SMAD6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |