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Antigenic Specificity | CEMIP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 1.7 mg/mL |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total CEMIP protein. Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manne |
Immunogen | Immunogen: Synthetic peptide of human CEMIP Immunogen Type: Peptide |
Other Names | [CCSP1; HYBID; TMEM2L; KIAA1199] |
Gene, Accession # | [CEMIP], Gene ID: 57214, NCBI: NP_001280227.1, UniProt: Q8WUJ3 |
Catalog # | MBS9430675 |
Price | $255 |
Order / More Info | CEMIP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |