Human SMAC/DIABLO Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Human SMAC/DIABLO |
| Clone | [2D12] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | ELISA; Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Human SMAC/DIABLO. SMAC/DIABLO (second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI) is a mitochondrial protein that functions as a regulatory component during apoptosis. It is encoded by a nuclear gene and is subsequently imported into the mitochondria where the N-terminus is removed generating the mature form of the molecule. SMAC/DIABLO has been shown to neutralize the antiapoptotic effect of the inhibitor of apoptosis protein (IAP) family, a major group of apoptosis regulators that have been shown to directly block caspase activity thereby blocking apoptosis. 1-6. |
| Immunogen | n/a |
| Other Names | [Mouse Human SMAC/DIABLO - Purified, Unlabeled; Mouse Human SMAC/DIABLO], [DIABLO; DIABLO; SMAC; SMAC3; DIABLO-S; FLJ10537; FLJ25049] |
| Gene, Accession # | Gene ID: 56616, UniProt: Q502X2 |
| Catalog # | MBS670144 |
| Price | $370 |
| Order / More Info | Human SMAC/DIABLO Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Verhagen, A.M., P.G. Ekert, M. Pakusch, J. Silke, L.M. Connolly, G.E. Reid, R.L. Moritz, R.J. Simpson, and D.L. Vaux. 2000. Cell 102:43.2. Hu, S., and X. Yang. 2003. J. Biol. Chem. 278:10055.3. Du, C., M. Fang, Y. Li, L. Li, and X. Wang. 2000. Cell 102:33.4. Adrain, C., E.M. Creagh and S.J. Martin. 2001. EMBO. 20:6627.5. Srinivasula, S.M., P.Datta, X. Fan, T. Fernandes-Alnemri, Z. Huang, and E.S. Alnemri. 2000. J. Biol. Chem. 275:36152.6. Ekert, P.G., J. Silke, C.J. Hawkins, A.M. Verhagen, and D.L. Vaux. 2001. J. Cell Biol. 152:483. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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