Leptin Receptor (LEPR) (N-term), 23-52 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Leptin Receptor (LEPR) (N-term), 23-52 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry-Paraffin (IHC-P) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This Leptin Receptor (LEPR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-52 amino acids from the N-terminal region of human Leptin Receptor (LEPR). Leptin, an adipocyte-specific hormone, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure by acting through the leptin receptor (LEPR). LEPR is a single-transmembrane-domain receptor of the cytokine receptor family that is identical to the mouse diabetes (db) gene product. During weight loss, leptin levels decrease, whereas soluble LEPR levels and the receptor bound fraction of leptin increases. The presence of LEPR in the absorptive cells of the small intestine suggests that leptin may have a physiologi |
| Immunogen | Function: Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalam |
| Other Names | [Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD295; LEPR; DB; OBR] |
| Gene, Accession # | [LEPR], Gene ID: 3953, NCBI: NP_001003679.1, UniProt: P48357 |
| Catalog # | MBS9204850 |
| Price | $165, $370 |
| Order / More Info | Leptin Receptor (LEPR) (N-term), 23-52 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Schroth, M., et al., J. Clin. Endocrinol. Metab. 88(11):5497-5501 (2003). Couturier, C., et al., J. Biol. Chem. 278(29):26604-26611 (2003). Gavrila, A., et al., J. Clin. Endocrinol. Metab. 88(6):2838-2843 (2003). Yannakoulia, M., et al., J. Clin. Endocrinol. Metab. 88(4):1730-1736 (2003). Kado, N., et al., Hum. Reprod. 18(4):715-720 (2003). |
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