MD-2, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | MD-2, Human |
| Clone | 18H10 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b |
| Format | fluorescein (FITC) conjugate |
| Size | 0.1 mg |
| Concentration | 100 ug/ml |
| Applications | Flow Cytometry (FC/FACS), FS |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody 18H10 reacts with MD-2, an accessory molecule of the Toll-like receptor 4 (TLR4, CD284). TLRs belong to a family of proteins that specifically recognizes and senses microbial products. They are highly conserved throughout evolution and act as innate immune recognition receptors against many pathogens. TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4. MD-2 exists as a cell surface protein in association with TLR4. It also exists as secreted forms consisting of MD-2 monomers and multimers (sMD-2). Circulating sMD-2 is mainly present as a doublet of ~20 and 25 kD, representin |
| Immunogen | Immunogen: TLR4/MD-2 expressing CHO cells/ chimeric TLR4/MD-2 fusion protein. Aliases: Lymphocyte antigen 96, ESOP-1, LY96. |
| Other Names | [Lymphocyte antigen 96, ESOP-1, LY96], [LY96; LY96; MD2; MD-2; ly-96; ESOP-1; ESOP1; MD2; Ly-96] |
| Gene, Accession # | [MD-2], Gene ID: 23643, NCBI: BAA78717.1 |
| Catalog # | MBS584029 |
| Price | $535 |
| Order / More Info | MD-2, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Pugin, J et al; Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock. Blood 2004, 104: 4071 2. Daubeuf, B et al; TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock. J Immunol 2007, 179: 6107 3. Elson, G et al; Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria. Blood 2007, 109: 1574 4. Tissieres, P et al; Soluble MD-2 is an acute phase protein and an opsonin for Gram-negative bacteria. Blood 2008, 111: 2122 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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