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Antigenic Specificity | RANK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The R12-31 monoclonal antibody reacts with mouse RANK, a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kappaB and c-Jun-terminal kinase pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kappaB, whereas JNK activation is mediated through binding of RANK to TRAF2. |
Immunogen | Immunogen: RANK antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human RANK as the immunogen |
Other Names | [Affinity Purified Rat RANK; RANK; RANK; Tnfrsf11a; Receptor Activator of NF-kB; Rank] |
Gene, Accession # | [RANK], Gene ID: 8792 |
Catalog # | MBS5312710 |
Price | $345 |
Order / More Info | RANK Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |