KALRN Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | KALRN |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: KALRN antibody detects endogenous levels of total KALRN. Function: Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.Subunit Structure: Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG.Post-translational Modifications: Autophosphorylated.Similarity: The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. Th |
| Immunogen | Immunogen: A synthesized peptide derived from human KALRN Subcellular Location: Cytoskeleton Tissue Specificity: Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle. Predicted Cross Reactivity: Horse, Rabbit Similarity: Horse (91%), Rabbit (80%) |
| Other Names | [Duo; FLJ16443; HAPIP; Huntingtin associated protein interacting protein (duo); Huntingtin-associated protein-interacting protein; Kalirin (isoform 2); Kalirin; KALRN; KALRN_HUMAN; Protein Duo; RhoGEF kinase; Serine/threonine kinase with Dbl and pleckstrin homology domains; Serine/threonine-protein kinase with Dbl-and pleckstrin homology domain; TRAD] |
| Gene, Accession # | [KALRN], Gene ID: 8997, NCBI: NP_001019831.2, UniProt: O60229 |
| Catalog # | MBS9603002 |
| Price | $240, $280 |
| Order / More Info | KALRN Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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