Pim-1 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Pim-1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to Human Pim-1. Pim proteins (Pim-1, Pim-2 and Pim-3) are oncogene-encoded serine/threonine kinases (1). Pim-1, a serine/threonine kinase highly expressed in hematopoietic cells, plays a critical role in the transduction of mitogenic signals and is rapidly induced by a variety of growth factors and cytokines (1-4). Pim-1 cooperates with c-Myc in lymphoid cell transformation and protects cells from growth factor withdrawal and genotoxic stress-induced apoptosis (5,6). Pim-1 also enhances the transcriptional activity of c-Myb through direct phosphorylation within the c-Myb DNA binding domain as well as phosphorylation of the transcriptional coactivator p100 (7,8). Hypermutations of the Pim-1 gene are found in B-cell diffuse |
| Immunogen | Immunogen: A synthetic -peptide of human Pim-1 |
| Other Names | [PIM1; Pim-1; Pim-1; PIM1; PIM; Proto-oncogene serine/threonine-protein kinase pim-1;], [PIM1; PIM1; PIM] |
| Gene, Accession # | Gene ID: 5292, NCBI: NP_001230115.1, UniProt: P11309 |
| Catalog # | MBS125957 |
| Price | $200, $275, $430 |
| Order / More Info | Pim-1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Mikkers, H. et al. (2004) Mol Cell Biol 24, 6104-15. 2. Selten, G. et al. (1986) Cell 46, 603-11. 3. Meeker, T.C. et al. (1987) J Cell Biochem 35, 105-12. 4. Dautry, F. et al. (1988) J Biol Chem 263, 17615-20. 5. Moroy, T. et al. (1993) Proc Natl Acad Sci USA 90, 10734-8. 6. Lilly, M. and Kraft, A. (1997) Cancer Res 57, 5348-55. 7. Leverson, J.D. et al. (1998) Mol Cell 2, 417-25. 8. Winn, L.M. et al. (2003) Cell Cycle 2, 258-62. 9. Pasqualucci, L. et al. (2001) Nature 412, 341-6. 10. Kim, O. et al. (2004) Oncogene 23, 1838-44. 11. Aho, T.L. et al. (2004) FEBS Lett 571, 43-9. 12. Yan, B. et al. (2003) J Biol Chem 278, 45358-67. 13. Saris, C.J. et al. (1991) EMBO J 10, 655-64. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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