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Antigenic Specificity | DNMT3a |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.5 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Polyclonal Antibody to detect DNMT3a in human, mouse and rat samples. Background: Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting, and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, three families of mammalian DNA methyltransferase genes have been identified which include DNMT1, DNMT2, and DNMT3. DNMT1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. DNMT2 is expressed at low levels in adult tissues and its inactivation does not affect |
Immunogen | Immunogen: Synthetic peptide at near N-terminal. Positive Control: Western blot: Jurket cell lysate |
Other Names | [DNA Methyltransferase 3a; DNMT3A], [DNMT3A; Dnmt3a; DNA MTase HsaIIIA; M.HsaIIIA] |
Gene, Accession # | [DNMT3a], Gene ID: 1788, NCBI: NP_072046.2, UniProt: Q9Y6K1 |
Catalog # | MBS840657 |
Price | $150, $325 |
Order / More Info | DNMT3a Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |