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Antigenic Specificity | RBL1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. |
Immunogen | Immunogen: Recombinant human Retinoblastoma-like protein 1 protein |
Other Names | [Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; p107; pRb1; RBL1] |
Gene, Accession # | [RBL1], Gene ID: 5933, NCBI: NP_002886.2, UniProt: P28749 |
Catalog # | MBS7001651 |
Price | $160, $235 |
Order / More Info | RBL1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |