CD166, Human Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | CD166, Human |
| Clone | AZN-L50 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), FS, Immunoflurescence (IF), Immunoprecipitation (IP), P, Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody AZN-L50 recognizes activated leukocyte cell adhesion molecule (ALCAM), a member of the immunoglobulin superfamily and has a characteristic VVC2C2C2 domain structure. ALCAM is a type I transmembrane protein of 100 kDa with five extracellular immunoglobulin-like domains and a short cytoplasmic tail. ALCAM mediates homotypic ALCAM-ALCAM interactions and heterotypic interactions with the T-cell antigen CD6. Homotypic interactions are involved in the development and maintenance of tissue architecture and tumor progression. Heterotypic interactions initiate and stabilize T-cell-dendritic interactions affecting T-cell activation. ALCAM is secreted as a NH2-terminal fragment of 30 kD. Soluble ALCAM (sALC |
| Immunogen | Immunogen: CD166 expressing K562 cells |
| Other Names | [Activated leukocyte cell adhesion molecule, ALCAM, CD166.], [ALCAM; ALCAM; MEMD; CD166; MEMD] |
| Gene, Accession # | [CD166], Gene ID: 214, NCBI: NP_001230212.1 |
| Catalog # | MBS584070 |
| Price | $470 |
| Order / More Info | CD166, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Kempen van, L et al; Molecular basis for the homophilic activated leukocyte cell adhesion molecule (ALCAM)-ALCAM interaction. J Biol Chem 2001, 276: 25783 2. Lunter, P et al; Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity. Cancer Res 2005, 65: 8801 3. Zimmerman, A et al; Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. Blood 2006, 107: 3212 4. Riet te, J et al; Distinct kinetic and mechanical properties govern ALCAM-mediated interactions as shown by single-molecule force spectroscopy. J Cell Sci 2007, 120: 3965 5. Bladergroen, B et al; Spatially separated distribution and highly flexible expression of adhesion molecules facilitates dynamic hematopoiesis. J Med Sci 2007, 7:1239 6. Kilsdonk van, J et al; Attenuation of melanoma invasion by a secreted variant of activated leukocyte cell adhesion molecule. Cancer Res 2008, 68:3671 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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