C5aR, Rat Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | C5aR, Rat |
| Clone | R63 |
| Host Species | Mouse |
| Reactive Species | rat |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody R63 reacts with the rat receptor for C5a (CD88). The rat anaphylatoxin C5a, a 77-amino acid glycopolypeptide generated by proteolytic cleavage of C5, is one of the most potent inflammatory chemo attractants and interacts with two C5a receptors, C5aR and C5L2.- Most of the C5a effects are mediated through C5aR. C5aR is known to be crucial in the initiation of acute inflammatory responses. C5a receptor is a seven transmembrane GTP-binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 45 kDa C5a receptor is expressed by leukocytes such as neutrophils, eosinophils, basophils, monocytes, dendritic cells and mast cells. C5aR can be expressed on both immune and non-immune |
| Immunogen | Immunogen: RBH-2H3 cells transfected with rat C5aR gene |
| Other Names | n/a |
| Gene, Accession # | [C5aR] |
| Catalog # | MBS584297 |
| Price | $665 |
| Order / More Info | C5aR, Rat Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Schlaf, G et al; Differential expression of the C5a receptor on the main cell types of rat liver as demonstrated with a novel monoclonal antibody and by C5a anaphylatoxin-induced Ca2 release. Lab Invest 1999, 79: 1287 2. Rothermel, E et al; Analysis of the tissue distribution of the rat C5a receptor and inhibition of C5a-mediated effects through the use of two MoAbs. Scand J Immunol 2000, 52: 401 3. Schieferdecker, H et al; Induction of functional anaphylatoxin C5a receptors on hepatocytes by in vivo treatment of rats with IL-6. J Immunol 2000, 164: 5453 4. Griffin, R et al; Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. J. Neurosc. 2007, 27: 8699 5. Woodruff, T et al; The complement factor C5a contributes to pathology in a rat model of amyoptrophic lateral sclerosis. J Immunol 2008, 181: 8727 6. Crane, J et al; The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres. J Neuroinflamation 2009, 6: 34 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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