NOXA Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | NOXA |
| Clone | [ABM16G6] |
| Host Species | Mouse |
| Reactive Species | human (predicted reactivity: mouse |
| Isotype | IgG1 kappa |
| Format | Protein G purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Noxa IS a BH3-only pro-apoptotic protein that mediates apoptosis by specifically inhibiting the anti-apoptotic Bcl-2 family member Mcl-1. It consists of 54 amino aCids with one BH3 domain. The gene for NOXA is a target of p53. In response to cellular stress Noxa is induced by p53 and mediates p53-induced apoptosis But more recently, it has been shown that NOXA can also be induced independently of p53 by other transcription factors such as p73 and E2F1. Noxa is also found to be induced by hypoxia-inducible factor (HIF-1) and mediates HIF-1 induced hypoxic cell death. Noxa is commonly upregulated in melanomas. and is associated with melanoma development and progression. Increase in Noxa expression is driven by oncogenic activation of MEK/ERK |
| Immunogen | Immunogen: A full length recombinant protein was used as the immunogen for this antibody. |
| Other Names | [phorbol-12-myristate-13-acetate-induced protein 1; Phorbol-12-myristate-13-acetate-induced protein 1; phorbol-12-myristate-13-acetate-induced protein 1; PMA-induced protein 1; adult T cell leukemia-derived PMA-responsive; immediate-early-response protein APR; protein Noxa; phorbol-12-myristate-13-acetate-induced protein 1; Immediate-early-response protein APR; Protein Noxa], [PMAIP1; PMAIP1; APR; NOXA; NOXA; PMA-induced protein 1] |
| Gene, Accession # | [NOXA], Gene ID: 5366, NCBI: NP_066950.1, UniProt: Q13794 |
| Catalog # | MBS668043 |
| Price | $290 |
| Order / More Info | NOXA Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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