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Antigenic Specificity | DDIT4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Required for mTORC1-mediated defense against viral protein synthesis and virus replication. Inhibits neuronal dif |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-232 of human DDIT4 (NP 061931.1). |
Other Names | [Dig2; REDD1; REDD-1] |
Gene, Accession # | [DDIT4], Gene ID: 54541, NCBI: NP_061931.1, UniProt: Q9NX09 |
Catalog # | MBS8548266 |
Price | $280 |
Order / More Info | DDIT4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |