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Antigenic Specificity | EED |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human EED (NP 003788.2). |
Other Names | [HEED; COGIS; WAIT1] |
Gene, Accession # | [EED], Gene ID: 8726, NCBI: NP_003788.2, UniProt: O75530 |
Catalog # | MBS8548747 |
Price | $280 |
Order / More Info | EED Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |