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Antigenic Specificity | ARF1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex ac |
Immunogen | Immunogen: Recombinant funsion protein containing a sequence corresponding to amino acids 1-181 of human ARF1 (NP 001649.1). |
Other Names | [ADP-ribosylation factor 1; ADP-ribosylation factor 1; ADP-ribosylation factor 1; ADP ribosylation factor 1] |
Gene, Accession # | [ARF1], Gene ID: 375, NCBI: P84077.2, UniProt: P84077 |
Catalog # | MBS8550304 |
Price | $280 |
Order / More Info | ARF1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |