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Antigenic Specificity | DFFA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Apoptosis is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF), heterodimer of 40-kDa (DFFB) and 45-kDa (DFFA) subunits, is one of the major endonucleases responsible for internucleosomal DNA cleavage during apoptosis. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF activated after cleavage of DFFA by caspase-3 followed by its dissociation from DFFB. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. DFFA appears to be a 45-kDa protein despite the predicated MW of 37 kDa. |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [Cleaved DFF45: DFF1; ICAD; DFF-45], [DFFA; DFFA; DFF1; ICAD; DFF-45; DFF1; DFF45; DFF-45; ICAD] |
Gene, Accession # | [DFFA], Gene ID: 1676, NCBI: O00273.1, UniProt: O00273 |
Catalog # | MBS125658 |
Price | $275, $430 |
Order / More Info | DFFA Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |