GSK3 beta Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | GSK3 beta |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-alpha dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-alpha is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex (2).Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world (3). Mutations have also been associ |
| Immunogen | Immunogen: Fusion protein of human MSH2. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [MSH2; COCA1; FCC1; HNPCC; HNPCC1; LCFS2], [MSH2; MSH2; FCC1; COCA1; HNPCC; LCFS2; HNPCC1; hMSH2] |
| Gene, Accession # | [GSK3 beta], Gene ID: 4436, NCBI: NP_000242.1, UniProt: P43246 |
| Catalog # | MBS858475 |
| Price | $290 |
| Order / More Info | GSK3 beta Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. O'Brien, V. and Brown, R. (2006) Carcinogenesis 27, 682-92. 2. Wang, Y. et al. (2000) Genes Dev 14, 927-39. 3. Plotz, G. et al. (2006) J Mol Histol 37, 271-83. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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