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Antigenic Specificity | NHERF1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit polyclonal to Human NHERF1. Na+/H+ exchanger regulatory factor (NHERF1 or EBP-50) is one of several related PDZ domain-containing proteins (1). NHERF1 was first identified as a necessary cofactor for cyclic AMP-associated inhibition of Na+/ H+ exchanger isoform 3 (NHE3) (2). NHERF1 is a multifunctional adaptor protein that interacts with receptors and ion transporters via its PDZ domains, and with the ERM family of proteins, including merlin, via its carboxy-terminus (2,3). NHERF1 may play an important role in breast cancer. Estrogen has been found to induce NHERF1 in estrogen receptor-positive breast cancer cells (2,3). Furthermore, NHERF1 has been shown to bind to PDGFR, which is activated in breast carcinomas. NHERF1 has been foun |
Immunogen | Immunogen: A Fusion protein of human NHERF1 |
Other Names | [SLC9A3R1; NHERF1; NHERF1; NHERF, NHERF1], [SLC9A3R1; SLC9A3R1; EBP50; NHERF; NHERF1; NHERF-1; NPHLOP2; NHERF; NHERF1; NHERF-1; EBP50] |
Gene, Accession # | Gene ID: 9368, NCBI: NP_004243.1, UniProt: O14745 |
Catalog # | MBS125205 |
Price | $200, $275, $430 |
Order / More Info | NHERF1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Donowitz, M. et al. (2005) J Physiol 567, 3-11. 2. Voltz, J.W. et al. (2001) Oncogene 20, 6309-14. 3. Stemmer-Rachamimov, A.O. et al. (2001) Am J Pathol 158, 57-62. 4. Takahashi, Y. et al. (2006) EMBO J 25, 910-20. 5. Wheeler, D. et al. (2007) J Biol Chem 282, 25076-87. 6. Weinman, E.J. et al. (2000) Am J Physiol Renal Physiol 279, F393-9. |