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Antigenic Specificity | Syntaphilin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin pl |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 18 amino acid peptide from near the amino terminus of human Syntaphilin. |
Other Names | [SNPH] |
Gene, Accession # | Gene ID: 9751, NCBI: NP_055538.2, UniProt: O15079 |
Catalog # | MBS9400775 |
Price | $320 |
Order / More Info | Syntaphilin Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |