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Antigenic Specificity | IRAK1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Interleukin-1 receptor-associated kinases (IRAKs) are a unique family of death domain containing protein kinases that play a key role in initiating innate immune response against foreign pathogens. They are involved in Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways. IRAK1 is the first member of this kinase family. Upon ligand binding to TLRIIL-1R, IRAK1 is recruited by MYD88 to the receptor-signaling complex., the association leads to IRAKI phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Hyper-phosphorylated IRAK1 then disengages from the receptor complex, and forms a cytosolic IRAK1-TRAF6 complex. TRAF6 then interacts with TAK and TAB, resulting in eventual activation of th |
Immunogen | Immunogen: Fusion protein of IRAK1 Calculated Molecular Weight: 68kd Observed Molecular Weight: 68-80kd |
Other Names | [IRAK; pelle] |
Gene, Accession # | [IRAK1], Gene ID: 3654, NCBI: NP_001020414.1 |
Catalog # | MBS2524193 |
Price | $195, $270, $435 |
Order / More Info | IRAK1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |