Edit |   |
---|---|
Antigenic Specificity | Girdin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total Girdin protein. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation By similarity. Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fi |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from Internal of human Girdin. |
Other Names | [APE; GIV; GRDN; HkRP1; Hook-related protein 1] |
Gene, Accession # | Gene ID: 55704, NCBI: NP_001129069.1, UniProt: Q3V6T2 |
Catalog # | MBS9412324 |
Price | $200, $255 |
Order / More Info | Girdin Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |