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Antigenic Specificity | Human CD29 |
Clone | [12G10] |
Host Species | Mouse |
Reactive Species | human, mink. does not react with: rat, mouse |
Isotype | IgG1 |
Format | fluorescein (FITC) conjugate |
Size | 0.1 mg |
Concentration | 1.0 mg/ml |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mouse anti Human CD29 monoclonal antibody, clone 12G10 recognizes human CD29 also known as beta1 integrin or VLA-4 subunit alpha. CD29 is a ~130 kDa under reducing, ~115 kDa under non-reducing conditions single pass type I transmembrane glycoprotein. CD29 acts as the common beta subunit of the heterodimeric very late antigens 1-6, complexing with CD49a-f respectively where it forms part of the receptors for laminin, collagen and fibronectin. the VLA heterodimers mediate cell-cell and cell-matrix interactions. Mouse anti Human CD29, clone 12G10 binding to cells adhering via VLA-4 results in actin cytoskeletal disruption and subsequent inhibition of attachment and spreading whilst 12G10 binding to cells adhering via VLA-5 results in enhanceme |
Immunogen | Immunogen: Purified human beta1 integrin preparation from HT1080 fibrosarcoma cell extract. Conjugation: FITC |
Other Names | [CD29 (12G10); Mouse Human CD29], [ITGB1; ITGB1; CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA; FNRB; MDF2; MSK12; GPIIA] |
Gene, Accession # | [CD29], Gene ID: 3688, NCBI: NP_002202.2, UniProt: P05556 |
Catalog # | MBS225641 |
Price | $370 |
Order / More Info | Human CD29 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |