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Antigenic Specificity | Human NRAS / N-ras |
Clone | polyclonal |
Host Species | Goat |
Reactive Species | human, mouse, bat, bovine, dog, horse, porcine (tested or 100% immunogen sequence identity). predicted . monkey, rat, guinea pig, hamster (at least 90% immunogen sequence identity) |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.05 mg |
Concentration | 0.5 mg/ml |
Applications | Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Human NRAS. The N-ras oncogene is a member of the RAS gene family. It is mapped on chromosome 1, and it is activated in HL60, a promyelocytic leukemia line. The order of nearby genes is as follows: cen--CD2--NGFB--NRAS--tel. The mammalian ras gene family consists of the harvey and kirsten ras genes (c-Hras1 and c-Kras2), an inactive pseudogene of each (c-Hras2 and c-Kras1) and the N-ras gene. They differ significantly only in the C-terminal 40 amino acids. These ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth. Mutations which change amino acid residues 12, 13 or 61 activate the potential of N-ras to transform culture |
Immunogen | Immunogen Description: Synthetic peptide C-RMKKLNSSDDGTQ from an internal region of human NRAS (NP_002515.1). Percent identity by BLAST analysis: Human, Orangutan, Gibbon, Monkey, Mouse, Elephant, Panda, Bovine, Dog, Bat, Horse, Pig, Opossum (100%). |
Other Names | [NRAS / N-ras (Internal) IHC-plus; NRAS; HRAS1; NRAS1; NS6; ALPS4; Transforming protein N-Ras; N-ras; N-ras protein part 4; GTPase NRas; Human NRAS; N-ras], [N-ras] |
Gene, Accession # | [NRAS], Gene ID: 4893, NCBI: NP_002515.1, UniProt: P01111 |
Catalog # | MBS242079 |
Price | $530 |
Order / More Info | Human NRAS / N-ras Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |